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Nursing Practice Questions

HESI Anatomy and Physiology Practice Questions

HESI Admission Assessment - Anatomy and Physiology Section — Practice with free HESI anatomy and physiology practice questions covering body systems, cells, homeostasis, and anatomical terminology. Each question includes a detailed explanation to help you understand the concepts, not just memorize answers.

27
Total Questions
~25 minutes (A&P section)
Time Limit
75-80% (varies by nursing program)
Passing Score
$70-$90 (full HESI A2, varies by testing center)
Registration Fee

Free Sample Questions

Here are 5 free sample questions from our full bank of 530+ HESI Anatomy and Physiologypractice questions. Try them out below — click "Show Answer" to reveal the correct response and explanation.

1

Which body system is primarily responsible for producing hormones that regulate metabolism, growth, and the body's response to stress?

ANervous system
BSkeletal system
CLymphatic system
DEndocrine system
2

Which cellular organelle is primarily responsible for generating ATP through aerobic respiration?

AGolgi apparatus
BRibosome
CMitochondrion
DLysosome
3

After a meal, blood glucose rises and the pancreas releases insulin to bring levels back down toward a normal set point. This is an example of which physiological mechanism?

ANegative feedback
BPositive feedback
CAutoregulation
DA reflex arc
4

A structure described as being closer to the midline of the body than another structure is said to be in which anatomical position?

ADistal
BMedial
CProximal
DSuperficial
5

During inhalation, which of the following best describes the primary muscular action responsible for expanding the thoracic cavity?

AThe diaphragm relaxes and moves upward
BThe intercostal muscles relax, reducing rib cage volume
CThe diaphragm contracts and moves downward, increasing thoracic volume
DThe abdominal muscles contract forcefully to pull air into the lungs

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About the HESI Anatomy and Physiology

Format & Structure

Total Questions
27
Time Limit
~25 minutes (A&P section)
Format
Multiple choice, computer-based

Scoring & Cost

Passing Score
75-80% (varies by nursing program)
Registration Fee
$70-$90 (full HESI A2, varies by testing center)

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Frequently Asked Questions

How many anatomy questions are on the HESI A2?

The Anatomy and Physiology section of the HESI A2 typically includes around 25 to 30 scored questions, though the exact count can vary slightly depending on your testing center and program. You'll usually get about 25 minutes to work through the section, so pacing matters almost as much as knowing the material.

What body systems are covered on the HESI A2 anatomy section?

Expect questions spanning the major body systems -- cardiovascular, respiratory, digestive, nervous, endocrine, musculoskeletal, and urinary, among others. You'll also see cellular biology (organelles, cell transport) and basic physiological processes like homeostasis. It's a broad survey rather than a deep dive into any single system, so wide coverage beats narrow memorization here.

How do I study for HESI anatomy and physiology?

Start with practice questions to figure out which systems trip you up, then go back to a review guide for those weak spots specifically. Flashcards work well for anatomical terminology (medial, lateral, proximal, distal) since those terms show up in disguised forms throughout the section. Most students find that a mix of practice questions and labeled diagrams sticks better than reading text alone.

What score do I need to pass the HESI A2 anatomy section?

Passing scores for HESI A2 sections generally fall between 75% and 80%, but this really does vary by nursing program -- some schools set a lower bar, others require a higher one. Check with your specific program's admissions office for their exact cutoff, since a passing score at one school might not clear the bar somewhere else.

How long is the HESI A2 anatomy and physiology section?

Most students are given roughly 25 minutes to complete the anatomy and physiology section. That works out to under a minute per question, so it helps to move past questions you're unsure of and come back if time allows rather than getting stuck early on.

Is HESI anatomy and physiology hard?

It's manageable if you've had a recent A&P course, but it can feel tough if it's been a while since you studied the material. The section leans heavily on terminology and system-level understanding rather than obscure trivia, so reviewing core concepts -- not memorizing every textbook detail -- tends to pay off the most.

What topics show up most on HESI A2 anatomy questions?

Cell structure and function, homeostasis and feedback mechanisms, anatomical terminology and directional terms, and the major organ systems all appear regularly. Physiology questions about how systems work together -- like how the respiratory and cardiovascular systems interact -- also come up more than people expect.

Can I retake the HESI A2 anatomy section if I fail?

Retake policies depend on your nursing program and testing center, not on HESI itself. Some schools allow a retake after 30 days, others have stricter limits on attempts per year. It's worth checking your program's specific policy before you register so you know what your options look like if things don't go your way the first time.

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